Cspg4-creert

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August undefined, 2024

WebCSPG4. Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan ( MCSP) or neuron-glial antigen 2 ( NG2 ), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. [5] [6] [7] WebFeb 2, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a multifunctional transmembrane proteoglycan involved in spreading, migration and invasion of melanoma. In addition to the activating BRAF V600E mutation, CSPG4 was shown to promote MAPK signaling by mediating the growth‑factor induced activation of receptor tyrosine kinases. …

Age-related myelin renewal and memory deficits in aging mice a,...

WebJun 18, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of … WebFeb 24, 2024 · BackgroundIn triple-negative breast cancer (TNBC), PDL1/PD1-directed immunotherapy is effective in less than 20% of patients. In our preliminary study, we have found CSPG4 to be highly expressed together with PDL1 in TNBCs, particularly those harboring TP53 aberrations. However, the clinical implications of co-expressed CSPG4 … bjt all formulas

CSPG4 Gene - GeneCards CSPG4 Protein CSPG4 Antibody

WebAug 19, 2014 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target antigen that is overexpressed in multiple cancer histologies including melanoma, triple-negative breast cancer, glioblastoma, mesothelioma and sarcoma. Methods: CSPG4 expression in cancer cell lines was assayed using flow cytometry (FACS) and reverse-transcription … Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. WebPlease remember that APCU will never request your personal information, online banking credentials or one time passcode via phone, email or text. If you receive a suspicious … bjs zero gravity massage chair

008538 - NG2-CreER[TM] Strain Details - The Jackson …

CSPG4 - Wikipedia

WebDownload scientific diagram Age-related myelin renewal and memory deficits in aging mice a, Schematic diagram displaying the time course of tamoxifen induction and histology in the Cspg4-CreERt ... Web2011. Age-dependent fate and lineage restriction of single NG2 cells. Zhu X , et al. PubMed: 21266410. MGI: J:167902. Development 138 (4):745-53. When using the NG2-CreER … bj-t01 flashlight manualWebArrows indicating Cspg4/mGFP double positive cells, n = 3 biologically independent mice for each group, two-tailed unpaired t test was used (t(4) = 0.2774, p = 0.7953), scale bar = … bjs wtby ct

"WebSep 27, 2016 · Lineage-specific tracing of remyelination by newly-formed oligodendrocytes was accomplished using the Cspg4-CreErt; Mapt-mGFP line.Recombination is induced by a single dose of tamoxifen in NG2 cells … " - Cspg4-creert

Cspg4-creert

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WebIn the current studies, we identify a tumor cell surface oncoantigen, chondroitin sulfate proteoglycan 4 (CSPG4), as an independent risk factor for decreased survival of patients with EOC. Our results show that CSPG4 promotes EOC cell invasion, cisplatin resistance and spheroid formation in vitro and tumor expansion in vivo. WebSPG4 Hereditary Spastic Paraplegia is caused by a gene mutation. Gene mutations are small errors in our DNA that can cause big problems. Patients with SPG4 have a …

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WebMar 16, 2024 · The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2 ... WebSep 27, 2016 · Lineage-specific tracing of remyelination by newly-formed oligodendrocytes was accomplished using the Cspg4-CreErt; Mapt-mGFP line. Recombination is induced by a single dose of tamoxifen in NG2 …

WebJun 26, 2024 · Neuro-glia antigen 2/chondroitin sulfate proteoglycan 4 (NG2/CSPG4, also called MCSP, HMW-MAA, MSK16, MCSPG, MEL-CSPG, or gp240) is a large cell-surface antigen and an unusual cell membrane integral glycoprotein frequently expressed on undifferentiated precursor cells in multiple solid organ cancers, including cancers of the … WebTumor cells were isolated from the pleural effusions of 12 patients with metastatic breast cancer and incubated sequentially with the chondroitin sulfate proteoglycan 4 (CSPG4)–specific monoclonal antibodies (mAbs) (225.28, 763.74, TP41.2, or TP61.5), phycoerythrin-labeled anti-mouse IgG antibodies, and fluorescein isothiocyanate–labeled …

WebDownload scientific diagram Segregating mGFP positive pericytes, OPCs and OLs in the Cspg4-CreERt; mT/mG brains a, The blood vessels (red) /pericytes (green) (mT/mG double positive) are ... WebArticle Snippet: Cspg4 CreERT2 mice were used to label cardiac pericytes during embryonic development and is a validated model to label Cspg4 expressing cells and …

WebDec 14, 2024 · The chondroitin sulfate proteoglycan 4 (CSPG4) gene encodes a transmembrane proteoglycan (PG) constituting the largest and most structurally complex macromolecule of the human surf aceome.Its transcript shows an extensive evolutionary conservation and, due to the elaborated intracellular processing of the translated protein, …

WebCSPG4 plays an important role in tumor cell growth and survival. These CSPG4-associated functional properties of tumor cells are inhibited by CSPG4-specific monoclonal antibodies (mAb) in vitro. Moreover, CSPG4-specific mAb can also inhibit tumor growth and metastasis in vivo. The anti-tumor effects of CSPG4-specific mAb are likely to reflect ... bjt and sonsWebCreERT系统实现了基因表达的时间控制，在时间要求精准的科学研究中大放异彩。例如，在记忆的研究中，CreERT系统（或TetTag系统），和即刻早期基因一起，经常作为基因 … bjt amplifiers compared bjt amplifier paperWebJan 24, 2024 · Mutation details: A cre/ERT2 open reading frame and Frt-flanked neomycin cassette replaced exon 1 of the Cspg4 (NG2) locus following homologous recombination in E14.1 ES cells. The neo cassette was deleted by crossing mice to flp expressing mice. No Cspg4 protein is detected in brain lysates. () bjt amplifier شرحWebThe CSPG4 and perlecan interaction is involved in cell adhesion and spreading. (A) MM200 cell adhesion on fibronectin coated surface was used as a positive control (i). MM200 cell adhesion on HCAEC perlecan coated surfaces, in the absence of antibody (ii), in the presence of antibodies against α2β1 integrin clone BHA2.1 (iii), against ... bjt amplifiers summaryWebTamoxifen诱导Cre-ERT2小鼠使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似 … dating for mature womenWebCreERT2-P2A expression cassette was knocked into the Cspg4 gene . Research Application ：Cre mouse,Perivascular cell or glial cell. dating format woman to man