WebFeb 21, 2024 · A total of 150 patients with gram-positive osteomyelitis were treated with ceftaroline fosamil. Most patients (117/150; 78.0%) were treated with 600 mg ceftaroline … Web- In almost every study reviewed, the median daptomycin dose was 6 mg/kg/day Daptomycin Dosing: - FDA-approved dose for BSI due to S. aureus is 6 mg/kg/day; however, VRE isolates generally demonstrate MICs 2- to 4-fold higher than those of S. aureus - 2 cohort studies demonstrated lower mortality when higher doses of …

What is the optimal dosing of daptomycin for VRE bacteremia?

WebNov 13, 2015 · Daptomycin is approved in adult patients, at a dose of 4 mg/kg/day for the treatment of complicated skin and soft tissue infections caused by Gram-positive bacteria, and at 6 mg/kg/day for right-sided endocarditis due to S. aureus and for bacteraemia associated with complicated skin and soft tissue infections or right-sided endocarditis [ 14 ]. notion research

Daptomycin Dosing and Use Guidelines - UC Davis

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. WebDec 11, 2024 · Daptomycin is FDA-approved for administration by the intravenous route. It is available as 350 mg sterile, preservative-free, pale yellow to light brown lyophilized powder for injection, reconstituted as 50 … WebCurrent medications include daptomycin 600 mg intravenous (IV) daily (6 mg/kg/Q24 hour), rifampin 300 mg per oral (PO) twice daily, aspirin, lisinopril, pantoprazole, tamsulosin, and PO hydrocortisone, levothyroxine, and subcutaneous heparin. how to share one notebook