Eukaryotic elongation factor 2 eef2

Author: tdyt

August undefined, 2024

WebSep 14, 2024 · Eukaryotic elongation factor 2 (eEF2), a key regulator of protein synthesis, is involved in the progression of several types of cancer. This first study was to investigate the relationships between eEF2 protein and prostate cancer (PCa). WebDec 15, 2024 · Maintenance of memory and synaptic plasticity relies on de novo protein synthesis, which is partially regulated by phosphorylation of …

Eukaryotic elongation factor 2 kinase confers tolerance to …

WebCRAE intervention increased the phosphorylation of eukaryotic elongation factor 2 (eEF2) in HCC cells, which blocked eEF2 activity for proceeding nascent protein synthesis. The activity of eEF2 was restored in CRAE-treated HCC cells in the presence of A484594, leading to the recovery of VEGF expression. WebSep 15, 2024 · We previously observed that administration of the GABA A R antagonist pentylenetetrazol or reduction of interneuron density resulted in dephosphorylation of eukaryotic elongation factor 2 (eEF2) in the mouse hippocampus . eEF2 is a GTP-dependent translocase that promotes the ribosomal translocation of peptidyl-tRNA during … san antonio round 1

EEF2 - Wikipedia

WebPhosphorylation of the mRNA translational factor eukaryotic elongation factor 2 (eEF2) by its specific kinase eEF2K is critically involved in protein synthesis regulation. In this … WebAug 6, 2012 · Eukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family, and an essential factor for protein synthesis and … WebDifferent lines of evidence indicate that eukaryotic elongation factor 2 (eEF2) can be ADP-ribosylated endogenously. The physiological significance of this reaction has, however, … san antonio rotary club scholarship

Medical Science Liaison (MSL), Neurology - LinkedIn

Oxidized LDL-Mediated Macrophage Survival Involves Elongation …

WebFeb 1, 2024 · Maintenance of memory and synaptic plasticity depend on de novo protein synthesis, dysregulation of which is implicated in AD. Recent studies showed AD-associated hyperphosphorylation of mRNA translation factor eukaryotic elongation factor 2 (eEF2), which results in inhibition of protein synthesis. http://genome-asia.ucsc.edu/cgi-bin/hgGene?hgsid=791935001_Zb8Rb17pSToEUN96aI1hciXsPMcL&hgg_section_method_close=1 san antonio roundersWebJul 30, 2004 · Eukaryotic elongation factor-2 (eEF2) mediates the translocation step of peptide-chain elongation and is inhibited through phosphorylation by eEF2 kinase. In addition, p70S6 kinase can regulate protein synthesis by phosphorylating eEF2 kinase or via phosphorylation of ribosomal protein S6. san antonio round table

"http://genome-asia.ucsc.edu/cgi-bin/hgGene?hgsid=792139420_nstD3VtgE9Fguka4YzALJnKvaLj6&hgg_section_method_close=1 " - Eukaryotic elongation factor 2 eef2

Eukaryotic elongation factor 2 eef2

Insights Into the Pathologic Roles and Regulation of Eukaryotic ...

WebDescription: Homo sapiens eukaryotic translation elongation factor 2 (EEF2), mRNA. (from RefSeq NM_001961) RefSeq Summary (NM_001961): This gene encodes a … WebCompare EEF2 (NM_001961) Human Tagged ORF Clone Lentiviral Particle from OriGene Technologies on Biocompare.com. Welcome Guest. Sign ... Human eukaryotic …

Did you know?

WebSep 24, 2014 · Eukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family that is essential for protein synthesis. eEF2 kinase (eEF2K) is a structurally and functionally unique protein kinase in the calmodulin-mediated signaling pathway. eEF2K phosphorylates eEF2, thereby inhibiting eEF2 function under … WebEukaryotic elongation factors (eEFs)2 such as eEF1A, eEF1B, and eEF2 are essential elements of the translational machineryincells.Inthisregard,eEF1ApromotestheGTP-dependent binding of aminoacyl-tRNAs to ribosomes, and eEF2,amonomericproteinof100kDa,isresponsibleforthe GTP-dependent translocation …

WebEukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family that is essential for protein synthesis. eEF2 kinase (eEF2K) is a … WebApr 5, 2024 · EEF2 phosphorylation by cyclin A-cyclin-dependent kinase 2 (CDK2) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K. Burn …

WebMar 18, 2024 · In the elongation process, eukaryotic elongation factor 2 (eEF2) binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate, which then allows the next AA-tRNA to enter the A site for translation elongation. The activity of eEF2 is negatively regulated by its kinase ... WebJan 25, 2016 · Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates the elongation stage of protein synthesis by phosphorylating and …

WebJan 9, 2012 · Further downstream analysis of mTOR pathway revealed enhanced phosphorylation of p70S6 kinase and associated diminished phosphorylation of eEF2 (eukaryotic translation elongation factor 2) in HIV/MPTECs; moreover, HIV/MPTECs displayed enhanced phosphorylation of eIF4B (eukaryotic translation initiation factor …

WebEukaryotic elongation factor 2 ( eEF2) Ribosomal translocase Translation elongation factor 2 Gene names Name EFT1 ORF names O3317, YOR3317W Ordered locus names YOR133W Name EFT2 Ordered locus names YDR385W Organism names Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) Taxonomic … san antonio rub and tugsWebEukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a calmodulin (CaM)-dependent protein kinase that negatively regulates protein translation. eEF2K has a catalytic domain at the N-terminus and phosphorylates eEF2, a specific … san antonio rv park near riverwalkWebWe also show that the calcium/calmodulin dependent kinase, eukaryotic elongation factor-2 kinase (eEF2 kinase), is activated in response to oxLDL, an effect that can be … san antonio routing numberWebPhosphorylation of the mRNA translational factor eukaryotic elongation factor 2 (eEF2) by its specific kinase eEF2K is critically involved in protein synthesis regulation. In this review, we discussed recent studies on the roles of eEF2K/eEF2signaling in the context of regulation/dysregulation of cognitive function and synaptic plasticity. san antonio rv spring branchWebProtein synthesis is highly regulated via both initiation and elongation. One mechanism that inhibits elongation is phosphorylation of eukaryotic elongation factor 2 (eEF2) on threonine 56 (T56) by eEF2 kinase (eEF2K). T56 phosphorylation inactivates eEF2 and is the only known normal eEF2 functional modification. san antonio saffe officersEukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G. This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the … See more • Hanes J, Freudenstein J, Rapp G, Scheit KH (April 1992). "Construction of a plasmid containing the complete coding region of human elongation factor 2". Biological Chemistry Hoppe-Seyler. 373 (4): 201–4. See more • Peptide+Elongation+Factor+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more san antonio rv in spring branchWebMar 10, 2011 · Mostly the eEF2 is regulated by phosphorylation and dephosphorylation by a specific kinase known as eEF2 kinase, which itself is up-regulated by various … san antonio safety conference 2023