WebPurpose: In PALOMA-2, palbociclib plus letrozole significantly improved progression-free survival (PFS) as initial treatment of estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer. We assessed the benefit of palbociclib plus letrozole in Asians. WebJun 26, 2024 · The PALOMA-2 trial, in which 666 patients have been randomized 2:1 between the AI and palbociclib arm and the AI and placebo arm, was the first to be …
PALOMA-2: Primary results from a phase III trial of palbociclib (P ...
WebOct 20, 2024 · quently, the randomized, phase 3 trial PALOMA-2 confirmed that palbociclib substantially pro-longed progression-free survival, in combination with letrozole, as first-line therapy for estrogen- WebNov 16, 2016 · PALOMA-2 is a randomized (2:1), multicenter, multinational, double-blind Phase 3 study designed to assess the PFS of IBRANCE (125 mg orally once daily for three out of four weeks in repeated cycles) in combination with letrozole (2.5 mg once daily continuously) versus letrozole plus placebo as a first-line treatment for postmenopausal … cheltenham replays today
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WebJan 19, 2024 · Patient-reported health-related QOL (HRQOL) outcomes, a secondary objective in the PALOMA-2 trial, were assessed using the fully validated Functional Assessment of Cancer Therapy-Breast (FACT-B) and EuroQOL 5 dimensions (EQ-5D) questionnaires at baseline, day 1 of cycles 2 and 3, and day 1 of every alternate cycle … PALOMA-2 was designed by an academic steering committee that included representatives from Pfizer, the industry sponsor (see the Supplementary Appendix, available with the full text of this article at NEJM.org). Pfizer supplied the investigators with the treatments used in the study. Data were … See more Hormone-receptorpositive breast cancer represents the largest therapeutic subtype of the disease, accounting for 60 to 65% of all malignant neoplasms of the breast. For more than 50 years, … See more The cyclin-dependent kinases (CDKs) are a large family of serinethreonine kinases that play an important role in regulating cell-cycle progression. The interaction of cyclin D with CDK4 … See more Women with ER-positive, HER2-negative advanced breast cancer were eligible for enrollment if they had not received prior systemic therapy for advanced disease. ER status was … See more In this double-blind, phase 3 study, patients were randomly assigned, in a 2:1 ratio, to receive 125 mg of palbociclib per day, administered … See more WebAug 16, 2024 · A total of 455 and 302 tumors from PALOMA-2 and PALOMA-3 trials, respectively, were successfully collected and analyzed for gene expression using the … flicker bulbs silicone