Triorganotin compounds all members
WebSynthesized compounds were initially evaluated on two cancer (HeLa and MCF-7) cell lines and cytotoxicity to normal cells was evaluated using a non-cancerous (BHK-21) cell line. All the compounds were found to be active, with IC 50 … Organotin chemistry is the scientific study of the synthesis and properties of organotin compounds or stannanes, which are organometallic compounds containing tin carbon bonds. The first organotin compound was diethyltin diiodide ((CH3CH2)2SnI2), discovered by Edward Frankland in 1849. The … See more Organotin compounds are generally classified according to their oxidation states. Tin(IV) compounds are much more common and more useful. Organic derivatives of tin(IV) The tetraorgano … See more Organotin compounds can be synthesised by numerous methods. Classic is the reaction of a Grignard reagent with tin halides for example tin tetrachloride. An example is provided by the synthesis of tetraethyltin: 4 CH3CH2MgBr + … See more The toxicities of tributyltin and triphenyltin derivatives compounds are comparable to that of hydrogen cyanide. Furthermore, tri-n-alkyltins are phytotoxic and therefore cannot be used in … See more • National Pollutant Inventory Fact Sheet for organotins • Industry information site • Organotin chemistry in synthesis See more Important reactions, discussed above, usually focus on organotin halides and pseudohalides with nucleophiles. In the area of organic synthesis, the Stille reaction is considered … See more An organotin compound is commercially applied as stabilizers in polyvinyl chloride. In this capacity, they suppress degradation by removing allylic chloride groups and by absorbing See more • Organostannane addition • Tributyltin azide • Carbastannatranes See more
Triorganotin compounds all members
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WebThe effects of currently synthesized triorganotin derivatives of the general formula R 3 SnX (R is butyl or phenyl, X is isothiocyanate), which are considered RXR ligands, were investigated in the human MDA-MB-231 breast cancer cell line. Studies were evaluated in the presence and absence of all-trans retinoic acid (ATRA), a natural RAR ligand.
WebFeb 26, 2024 · Both commercially unavailable compounds consist of two active groups (triorganotin and isothiocyanate) and were used to test their effect on protein expression … WebApr 2, 2015 · We review trialkyltin and triaryltin compounds, representing a class of organometallic compounds that function as nuclear retinoid X receptors (RXR) agonists …
Web69536-57-8. Dibutyltin diisooctylthioglycolate (primary CASRN is 25168-24-5) 70620-28-9. Dibutyltin dilaurate (primary CASRN is 77-58-7) 7324-74-5. benzyl (Z,Z)-8,8-dibutyl-3,6,10 … WebAnti-proliferative potential of triorganotin ( iv) carboxylates depicted that in both cancer cell lines methyl substitution yielded least potent compound ( C1 ), while butyl substitution …
WebA series of triorganotin chrysanthemumates (2,2-dimethyl-3- (2-methyl-1-propenyl)cyclopropanecarboxylates) (R3SnO2CC9H15) where R = methyl, ethyl, n-butyl and phenyl was synthesized. The solid state… Expand 3 Tolerance of Aedes aegypti larvae to triorganotins Thanh-Truc Nguyen, Nwaka Ogwuru, G. Eng Chemistry 2000
WebSep 29, 2012 · It is well known that organotin (IV) compounds display strong biological activity. The triorganotin compound [ (C (6)H (5)) (3)Sn (cmbzt)] (cmbzt=5-chloro-2-mercaptobenzothiazole) (SnCMB), was tested for its antiproliferative and … mahesh bhatt parveen babiWebJan 1, 2024 · The formulas of the investigated compounds are shown in Table 1. Both commercially unavailable compounds consist of two active groups (triorganotin and isothiocyanate) and were used to test their effect on protein expression in the human breast cancer triple-negative MDA-MB-231 cells. o2 town hall newcastleWebC. Esser, in Comprehensive Medicinal Chemistry II, 2007 5.09.4.2.2.2 Organotin compounds. Organotin compounds are chemicals with at least one covalent Sn–C bond. They are … mahesh bhatt kissed his daughterWebMay 27, 1975 · Terpyridyl is reported to have no reaction with triorganotin halides [21. The following compounds have been isolated: (CH3)3SnCI -L; (C6H5 )3SnCI - L (L = 1,11) and (C6H5)3Sri (NCS)-L ( L = I). The compounds are all buff or yellow stabie crystalline solids which behave as non-electrolytes in nitrobenzene. mahesh bhatt office addressWebAug 4, 2010 · Triorganotin compounds are biologically active. They represent a smaller tonnage market – between 15 and 20% of total organotin world manufacture. Triorganotin compounds have an important place in the agrochemical field as fungicides and miticides, with the production and use of about 5000 tonnes per annum. o2 tv by waipuWebMar 28, 2024 · There is no evidence that organotin compounds are carcinogenic or teratogenic. Reported effects of triphenyltin hydroxide on the testes and ovaries of rats require further confirmation. Information concerning the mechanism of the toxic action of organotin compounds is inadequate. mahesh bhatt pooja bhatt relationshipWebFrom this study it is concluded that the lower trialkyltins (TMTC, TETC) are essentially neurotoxic, the intermediate trialkytins (TPTC, TBTC) and triphenyltin are primarily immunotoxic, and the higher homologs (THTC, TOTC) are only slightly toxic or not toxic at all. Publication types Comparative Study o2 tv business sport plus